The horizontal dotted line represents CCP with no effect (OR = 1). Marker values are expressed as standard deviations of log values centered around the mean (standardized log). The top row presents the trends in CCP effect compared to SOC as a function of the marker value, along with 95% CIs. b, Effect-modifying role of CCP content for the primary outcome for each marker. Center line: median box limits: 25th and 75th percentiles whiskers: 1.5× IQR points: outliers. Transfusion of convalescent plasma with unfavorable antibody profiles could be associated with worse clinical outcomes compared to standard care.Ī, Absolute antibody amounts transfused per patient ( n = 597) in the CCP arm for each marker, expressed as the product of volume and concentration. Convalescent plasma did not reduce the risk of intubation or death at 30 d in hospitalized patients with COVID-19. In multivariate analysis, each standardized log increase in neutralization or antibody-dependent cellular cytotoxicity independently reduced the potential harmful effect of plasma (odds ratio (OR) = 0.74, 95% CI 0.57-0.95 and OR = 0.66, 95% CI 0.50-0.87, respectively), whereas IgG against the full transmembrane spike protein increased it (OR = 1.53, 95% CI 1.14-2.05). The antibody content significantly modulated the therapeutic effect of convalescent plasma. Patients in the convalescent plasma arm had more serious adverse events (33.4% versus 26.4% RR = 1.27, 95% CI 1.02-1.57, P = 0.034). Intubation or death occurred in 199/614 (32.4%) patients in the convalescent plasma arm and 86/307 (28.0%) patients in the standard of care arm-relative risk (RR) = 1.16 (95% confidence interval (CI) 0.94-1.43, P = 0.18). In total, 940 patients were randomized, and 921 patients were included in the intention-to-treat analysis. The trial was terminated at 78% of planned enrollment after meeting stopping criteria for futility. Exploratory analyses of the effect of convalescent plasma antibodies on the primary outcome was assessed by logistic regression. The composite primary outcome was intubation or death by 30 d. Patients were allocated 2:1 to 500 ml of convalescent plasma or standard of care. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset ( NCT04348656 ). Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. In addition to helping you sell your home, I can help you find a reputable firm at your destination and help you manage the move.The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. If you're moving somewhere else in or out of the area, let my relocation team at Patterson-Schwartz make the transition easier. Step Five: Moving Locally, Nationally or Internationally If you're interested in listing your home with me,īegin here. Because of Patterson-Schwartz's leadership in the area, I have resources no other firm can match. This is a combination of a solid marketing plan, targeted media exposure, and taking advantage of our powerful network of local and out-of-town buyers. Getting the best price is about bringing you the right buyers for your house. My experience combined with my association with Patterson-Schwartz Real Estate, the area's dominant market leader, will help ensure your real estate success. My local knowledge of home values and expertise in pricing and negotiating are important assets in getting the most for your house. You may request a Comparative Market Analysis and personal consultationĮnlisting the services of a Realtor®, like myself, helps you better understand the selling process and gives you a number of advantages in selling your home. I welcome the opportunity to prepare and review with you, a Comparative Market Analysis (CMA) for your home. In today's housing environment, having a professional who understands home values and current local real estate market conditions is critical to achieving this goal. Setting the right price before you list is often the most difficult decision and ultimately the key to getting the most for your home and selling it quickly. To receive a complimentary consultation and learn about how I can help,īegin here. I can help you focus your effort on the things that will make a real difference to buyers and are worth your investment. Step One: Prepare to SellĪs you get ready to sell your home, there are usually some simple improvements that can help you get the most for your house and sell it quickly. View the latest seasonal guide on things to consider when selling a home. To help you get started, I have outlined the key steps to selling and the ways that I can provide assistance. Share via Email Share on Facebook Share on Twitter Pin It
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